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Opana is an Oxymorphone powerful semi-synthetic opioid analgesic (painkiller). The duration of pain relief is 3–4 hours for immediate- release tablets and 12 hours for extended-release tablets. It was first manufactured in 1914 in Germany, invented in the USA by Endo Pharmaceuticals in 1955 and introduced in the USA in January 1959 and other countries around the same time